Background: Many planetary nebulae retain significant quantities of molecular gas and dust despite their signature hostile radiation environments and energetic shocks. Photoionization and dissociation by extreme UV and (often) X-ray emission from their central stars drive the chemical processing of this material. Their well-defined geometries make planetary nebulae ideal testbeds for modeling the effects of radiation-driven heating and chemistry on molecular gas in photodissociation regions. Methods: We have carried out IRAM 30m/APEX 12m/ALMA radio studies of the Helix Nebula and its molecule-rich globules, exploiting the unique properties of the Helix to follow up our discovery of an anti-correlation between HNC/HCN line intensity ratio and central star UV Luminosity. Results: Analysis of HNC/HCN across the Helix Nebula reveals the line ratio increases with distance from the central star, and thus decreasing incident UV flux, indicative of the utility of the HNC/HCN ratio as a tracer of UV irradiation in photodissociation environments. However, modeling of the observed regions suggests HNC/HCN should decrease with greater distance, contrary to the observed trend. Conclusion: HNC/HCN acts as an effective tracer of UV irradiation of cold molecular gas. Further model studies are required.