AbstractPlanet formation takes place in the gaseous and dusty disks that surround young stars, known as protoplanetary disks. With the advent of sensitive observations and together with developments in theory, our field is making rapid progress in understanding how the evolution of protoplanetary disks takes place, from its inception to the end result of a fully-formed planetary system. In this review, I discuss how observations that trace both the dust and gas components of these systems inform us about their evolution, mass budget, and chemistry. Particularly, the process of disk evolution and planet formation will leave an imprint on the distribution of solid particles at different locations in a protoplanetary disk, and I focus on recent observational results at high angular resolution in the sub-millimeter regime, which have revealed a variety of substructures present in these objects.