AbstractLarge-amplitude asymptotic giant branch variables potentially rival Cepheid variables as fundamental calibrators of the distance scale, particularly if observations are made in the infrared, or where there is substantial interstellar obscuration. They are particularly useful for probing somewhat older populations, such as those found in dwarf spheroidal galaxies, elliptical galaxies or in the haloes of spirals. Calibration data from the Galaxy and new observations of various Local Group galaxies are described and the outlook for the future, with a calibration from Gaia and observations from the next generation of infrared telescopes, is discussed.