AbstractCertain types of large amplitude AGB variable are proving to be powerful distance indicators that will rival Cepheids in the James Webb Space Telescope era of high precision infrared photometry. These are predominantly found in old populations and have low mass progenitors. At the other end of the AGB mass-scale, large amplitude variables, particularly those undergoing hot bottom burning, are the most luminous representatives of their population. These stars are < 1 Gyr old, are often losing mass copiously and are vital to our understanding of the integrated light of distant galaxies as well as to chemical enrichment. However, the evolution of such very luminous AGB variables is rapid and remains poorly understood. Here I discuss recent infrared observations of both low- and intermediate-mass Mira variables in the Local Group and beyond.