During the two weeks between 19 February and 2 March 2018, the Office for Science at Vitacura and the La Silla Observatory were the hosts of the second ESO/NEON (Network of European Observatories in the North) La Silla Observing School. Thanks to the generous funding from ESO, the Optical Infrared Coordination Network for Astronomy (OPTICON), and the La Silla Observatory, a group of 20 students, consisting of mostly PhD but also some advanced MSc students, from different parts of the world, were guided by five ESO tutors. The students prepared and carried out complex observations, reduced and analysed the data, and finally presented the results to the ESO scientific community at Vitacura. In addition to learning about the observing techniques that were used during the school, the students also attended several lectures covering the current and future capabilities of the Atacama Large Millimeter/submillimeter Array (ALMA), the telescopes at Paranal, and the Extremely Large Telescope (ELT), as well as talks on what makes a good scientific presentation, time management, effective proposal writing, and career choices.