Abstract We use the EAGLE simulations to study the effects of the intra-cluster medium (ICM) on the spatially resolved star-formation activity in galaxies. We study three cases of galaxy asymmetry dividing each galaxy in two halves using the plane (i) perpendicular to the velocity direction, differentiating the galaxy part approaching to the cluster center, hereafter dubbed as the “leading half”, and the opposite one “trailing half”, (ii) perpendicular to the radial position of the satellite to the centre of the cluster, (iii) that maximizes the star-formation rate ($\rm SFR$) difference between the two halves. For (i), we find an enhancement of the $\rm SFR$, star formation efficiency ($\rm SFE$), and interstellar medium pressure in the leading half with respect to the trailing one and normal star-forming galaxies in the EAGLE simulation, and a clear overabundance of gas particles in their trailing. These results suggest that ram pressure (RP) is boosting the star formation by gas compression in the leading half, and transporting the gas to the trailing half. This effect is more pronounced in satellites of intermediate stellar masses $\rm 10^{9.5-10.5} M_{⊙ }$, with gas masses above $\rm 10^{9} M_{⊙ }$, and located within one virial radius or in the most massive clusters. In (iii) we find an alignment between the velocity and the vector perpendicular to the plane that maximizes the $\rm SFR$ difference between the two halves. It suggests that finding this plane in real galaxies can provide insights into the velocity direction.