ABSTRACT The majority of the activity around nearby (z ≈ 0) supermassive black holes is found in low-luminosity active galactic nuclei (LLAGN), the most of them being classified as low-ionization nuclear emission regions. Although these sources are well studied from radio up to X-rays, they are poorly understood in γ-rays. In this work, we take advantage of the all sky-surveying capabilities of the Large Area Telescope on board Fermi Gamma-ray Space Telescope to study the whole Palomar sample of LLAGN in γ-rays. Precisely, the four radio-brightest LLAGN in the sample are identified as significant γ-ray emitters, all of which are recognized as powerful Fanaroff–Riley I galaxies. These results suggest that the presence of powerful radio jets is of substantial importance for observing a significant γ-ray counterpart even if these jets are misaligned with respect to the line of sight. We also find that most of the X-ray-brightest LLAGN do not have a significant γ-ray and strong radio emission, suggesting that the X-rays come mainly from the accretion flow in these cases. A detailed analysis of the spectral energy distributions (SEDs) of NGC 315 and NGC 4261, both detected in γ-rays, is provided where we make a detailed comparison between the predicted hadronic γ-ray emission from a radiatively inefficient accretion flow (RIAF) and the γ-ray emission from a leptonic jet-dominated synchrotron self-Compton (SSC) model. Both SEDs are better described by the SSC model, while the RIAF fails to explain the γ-ray observations.