ABSTRACT Post-starburst galaxies, identified by their unusually strong Balmer absorption lines and weaker than average emission lines, have traditionally been selected based on their central stellar populations. Here we identify 360 galaxies with post-starburst regions from the MaNGA integral field survey and classify these galaxies into three types: 31 galaxies with central post-starburst regions (CPSB), 37 galaxies with off-centre ring-like post-starburst regions (RPSB), and 292 galaxies with irregular post-starburst regions (IPSB). Focusing on the CPSB and RPSB samples, and comparing their radial gradients in Dn4000, HδA, and W(H α) to control samples, we find that while the CPSBs have suppressed star formation throughout their bulge and disc, and there is clear evidence of rapid decline of star formation in the central regions, the RPSBs only show clear evidence of recently rapidly suppressed star formation in their outer regions and an ongoing central starburst. The radial profiles in mass-weighted age and stellar v/σ indicate that CPSBs and RPSBs are not simply different evolutionary stages of the same event, rather the CPSB galaxies are caused by a significant disruptive event, while the RPSB galaxies are caused by disruption of gas fuelling to the outer regions. Compared to the control samples, both CPSB and RPSB galaxies show a higher fraction of interactions/mergers, misaligned gas, or bars that might be the cause of the gas inflows and subsequent quenching.