AbstractWe present results from our ongoing monitoring programs aimed at identifying and understanding Active Galactic Nuclei (AGN) in extreme flux and spectral states. Observations of AGN in extreme states can reveal the nature of the inner accretion flow, the physics of matter under strong gravity, and they provide insight on the properties of ionized absorbers and outflows launched near supermassive black holes (SMBHs). We present new results from our long-term monitoring of IC 3599, WPVS007, and Mrk 335, multi-wavelength follow-ups of the newly identified changing-look AGN HE 1136–2304, and UV–X-ray follow-ups of the binary SMBH candidate OJ 287 after its 2015 optical maximum, now in a new optical-X-ray–high-state.