Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Willems, Sara M.; Wright, Daniel J.; Day, Felix R.; Trajanoska, Katerina; Joshi, Peter K.; Morris, John A.; Matteini, Amy M.; Garton, Fleur C.; Grarup, Niels; Oskolkov, Nikolay; Thalamuthu, Anbupalam; Mangino, Massimo; Liu, Jun; Demirkan, Ayse; Lek, Monkol; Xu, Liwen; Wang, Guan; Oldmeadow, Christopher; Gaulton, Kyle J.; Lotta, Luca A.; Miyamoto-Mikami, Eri; Rivas, Manuel A.; White, Tom; Loh, Po-Ru; Aadahl, Mette; Amin, Najaf; Attia, John R.; Austin, Krista; Benyamin, Beben; Brage, Søren; Cheng, Yu-Ching; Cięszczyk, Paweł; Derave, Wim; Eriksson, Karl-Fredrik; Eynon, Nir; Linneberg, Allan; Lucia, Alejandro; Massidda, Myosotis; Mitchell, Braxton D.; Miyachi, Motohiko; Murakami, Haruka; Padmanabhan, Sandosh; Pandey, Ashutosh; Papadimitriou, Ioannis; Rajpal, Deepak K.; Sale, Craig; Schnurr, Theresia M.; Sessa, Francesco; Shrine, Nick; Tobin, Martin D.; Varley, Ian; Wain, Louise V.; Wray, Naomi R.; Lindgren, Cecilia M.; MacArthur, Daniel G.; Waterworth, Dawn M.; McCarthy, Mark I.; Pedersen, Oluf; Khaw, Kay-Tee; Kiel, Douglas P.; Oei, Ling; Zheng, Hou-Feng; Forgetta, Vincenzo; Leong, Aaron; Ahmad, Omar S.; Laurin, Charles; Mokry, Lauren E.; Ross, Stephanie; Elks, Cathy E.; Bowden, Jack; Warrington, Nicole M.; Murray, Anna; Ruth, Katherine S.; Tsilidis, Konstantinos K.; Medina-Gómez, Carolina; Estrada, Karol; Bis, Joshua C.; Chasman, Daniel I.; Demissie, Serkalem; Enneman, Anke W.; Hsu, Yi-Hsiang; Ingvarsson, Thorvaldur; Kähönen, Mika; Kammerer, Candace; Lacroix, Andrea Z.; Li, Guo; Liu, Ching-Ti; Liu, Yongmei; Lorentzon, Mattias; Mägi, Reedik; Mihailov, Evelin; Milani, Lili; Moayyeri, Alireza; Nielson, Carrie M.; Sham, Pack Chung; Siggeirsdotir, Kristin; Sigurdsson, Gunnar; Stefansson, Kari; Trompet, Stella; Thorleifsson, Gudmar; Vandenput, Liesbeth; van der Velde, Nathalie; Viikari, Jorma; Xiao, Su-Mei; Zhao, Jing Hua; Evans, Daniel S.; Cummings, Steven R.; Cauley, Jane; Duncan, Emma L.; de Groot, Lisette C. P. G. M.; Esko, Tonu; Gudnason, Vilmundar; Harris, Tamara B.; Jackson, Rebecca D.; Jukema, J. Wouter; Ikram, Arfan M. A.; Karasik, David; Kaptoge, Stephen; Kung, Annie Wai Chee; Lehtimäki, Terho; Lyytikäinen, Leo-Pekka; Lips, Paul; Luben, Robert; Metspalu, Andres; van Meurs, Joyce B. J.; Minster, Ryan L.; Orwoll, Erick; Oei, Edwin; Psaty, Bruce M.; Raitakari, Olli T.; Ralston, Stuart W.; Ridker, Paul M.; Robbins, John A.; Smith, Albert V.; Styrkarsdottir, Unnur; Tranah, Gregory J.; Thorstensdottir, Unnur; Uitterlinden, Andre G.; Zmuda, Joseph; Zillikens, M. Carola; Ntzani, Evangelia E.; Evangelou, Evangelos; Ioannidis, John P. A.; Evans, David M.; Ohlsson, Claes; Pitsiladis, Yannis; Fuku, Noriyuki; Franks, Paul W.; North, Kathryn N.; van Duijn, Cornelia M.; Mather, Karen A.; Hansen, Torben; Hansson, Ola; Spector, Tim; Murabito, Joanne M.; Richards, J. Brent; Rivadeneira, Fernando; Langenberg, Claudia; Perry, John R. B.; Wareham, Nick J.; Scott, Robert A.

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Willems et al., 2017

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Nature Research (part of Springer Nature), Nature Communications, (8), p. 16015

DOI: 10.1038/ncomms16015

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@article{Willems2017,
  author = {Willems, Sara M. and Wright, Daniel J. and Day, Felix R. and Trajanoska, Katerina and Joshi, Peter K. and Morris, John A. and Matteini, Amy M. and Garton, Fleur C. and Grarup, Niels and Oskolkov, Nikolay and Thalamuthu, Anbupalam and Mangino, Massimo and Liu, Jun and Demirkan, Ayse and Lek, Monkol and Xu, Liwen and Wang, Guan and Oldmeadow, Christopher and Gaulton, Kyle J. and Lotta, Luca A. and Miyamoto-Mikami, Eri and Rivas, Manuel A. and White, Tom and Loh, Po-Ru and Aadahl, Mette and Amin, Najaf and Attia, John R. and Austin, Krista and Benyamin, Beben and Brage, Søren and Cheng, Yu-Ching and Cięszczyk, Paweł and Derave, Wim and Eriksson, Karl-Fredrik and Eynon, Nir and Linneberg, Allan and Lucia, Alejandro and Massidda, Myosotis and Mitchell, Braxton D. and Miyachi, Motohiko and Murakami, Haruka and Padmanabhan, Sandosh and Pandey, Ashutosh and Papadimitriou, Ioannis and Rajpal, Deepak K. and Sale, Craig and Schnurr, Theresia M. and Sessa, Francesco and Shrine, Nick and Tobin, Martin D. and Varley, Ian and Wain, Louise V. and Wray, Naomi R. and Lindgren, Cecilia M. and MacArthur, Daniel G. and Waterworth, Dawn M. and McCarthy, Mark I. and Pedersen, Oluf and Khaw, Kay-Tee and Kiel, Douglas P. and Oei, Ling and Zheng, Hou-Feng and Forgetta, Vincenzo and Leong, Aaron and Ahmad, Omar S. and Laurin, Charles and Mokry, Lauren E. and Ross, Stephanie and Elks, Cathy E. and Bowden, Jack and Warrington, Nicole M. and Murray, Anna and Ruth, Katherine S. and Tsilidis, Konstantinos K. and Medina-Gómez, Carolina and Estrada, Karol and Bis, Joshua C. and Chasman, Daniel I. and Demissie, Serkalem and Enneman, Anke W. and Hsu, Yi-Hsiang and Ingvarsson, Thorvaldur and Kähönen, Mika and Kammerer, Candace and Lacroix, Andrea Z. and Li, Guo and Liu, Ching-Ti and Liu, Yongmei and Lorentzon, Mattias and Mägi, Reedik and Mihailov, Evelin and Milani, Lili and Moayyeri, Alireza and Nielson, Carrie M. and Sham, Pack Chung and Siggeirsdotir, Kristin and Sigurdsson, Gunnar and Stefansson, Kari and Trompet, Stella and Thorleifsson, Gudmar and Vandenput, Liesbeth and van der Velde, Nathalie and Viikari, Jorma and Xiao, Su-Mei and Zhao, Jing Hua and Evans, Daniel S. and Cummings, Steven R. and Cauley, Jane and Duncan, Emma L. and de Groot, Lisette C. P. G. M. and Esko, Tonu and Gudnason, Vilmundar and Harris, Tamara B. and Jackson, Rebecca D. and Jukema, J. Wouter and Ikram, Arfan M. A. and Karasik, David and Kaptoge, Stephen and Kung, Annie Wai Chee and Lehtimäki, Terho and Lyytikäinen, Leo-Pekka and Lips, Paul and Luben, Robert and Metspalu, Andres and van Meurs, Joyce B. J. and Minster, Ryan L. and Orwoll, Erick and Oei, Edwin and Psaty, Bruce M. and Raitakari, Olli T. and Ralston, Stuart W. and Ridker, Paul M. and Robbins, John A. and Smith, Albert V. and Styrkarsdottir, Unnur and Tranah, Gregory J. and Thorstensdottir, Unnur and Uitterlinden, Andre G. and Zmuda, Joseph and Zillikens, M. Carola and Ntzani, Evangelia E. and Evangelou, Evangelos and Ioannidis, John P. A. and Evans, David M. and Ohlsson, Claes and Pitsiladis, Yannis and Fuku, Noriyuki and Franks, Paul W. and North, Kathryn N. and van Duijn, Cornelia M. and Mather, Karen A. and Hansen, Torben and Hansson, Ola and Spector, Tim and Murabito, Joanne M. and Richards, J. Brent and Rivadeneira, Fernando and Langenberg, Claudia and Perry, John R. B. and Wareham, Nick J. and Scott, Robert A.},
  doi = {10.1038/ncomms16015},
  journal = {Nature Communications},
  month = {jul},
  pages = {16015},
  title = {Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness},
  url = {https://doi.org/10.1038/ncomms16015},
  volume = {8},
  year = {2017}
}

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