During the last years, many solutions have been proposed for 3D Virtual Heritage representations. Recently, also new technologies for online gaming evolved, based on javascript libraries (WebGL), used to create and publish virtual interactive environments. They are based on recent Web browser’s functionalities, surpassing some limitations of VRML technologies. On the side of geospatial information, technology has evolved from desktop GIS to 2D WebGIS and globe applications. The use of globe applications is, today, very diffused due to its immediate and at the same time impressive representation of the earth surface and territories. These technologies have been, also, applied to Virtual Heritage 3D reconstructions, to improve the fruition of Cultural Heritage (CH), with the achievement of interesting results. The topic of this paper is the experimentation on the fusion between globe based and gaming technologies (in our case WebGL) that allow achieving a more user-centric and powerful solution useful for publishing 3D geospatial information of CH on Web. This choice allows obtaining GIS oriented 3D models, typical of globe applications, and, at the same time, a more immersive exploration of CH and its surrounding environment. In particular, it also gives complementary text and multimedia information on the history, architectural features of each cultural good, based on querying of semantic information. The test field of the research is the construction of the 3D GIS virtual globe model of the Manfredonic Castle of Mussomeli (Sicily-Italy), developed for PON-NEPTIS EU Project, to compare open-source technologies and commercial proprietary applications.