We investigate the ionospheric response to solar Extreme Ultraviolet (EUV) variations using different proxies, based on solar EUV spectra observed from the Solar Extreme Ultraviolet Experiment (SEE) onboard the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite, the F10.7 index (solar irradiance at 10.7 cm), and the Bremen composite Mg-II index during January 2003 to December 2016. The daily mean solar proxies are compared with global mean Total Electron Content (GTEC) values calculated from global IGS TEC maps. The preliminary analysis shows a significant correlation between GTEC and both the integrated flux from SEE and the Mg II index, while F10.7 correlates less strongly with GTEC. The correlations of EUV proxies and GTEC at different time periods are presented. An ionospheric delay in GTEC is observed at the 27 days solar rotation period with the time scale of about ∼ 1–2 days. An experiment with the physics based global 3-D Coupled Thermosphere/Ionosphere Plasmasphere electrodynamics (CTIPe) numerical model was performed to reproduce the ionospheric delay. Model simulations were performed for different values of the F10.7 index while keeping all the other model inputs constant. Preliminary results qualitatively reproduce the observed ∼ 1–2 days delay in GTEC, which is might be due to vertical transport processes.