The Tibetan Plateau uplift and its linkages with the evolution of the Asian climate during the Cenozoic are a research focus for numerous geologists. Here, a comprehensive review of tectonic activities across the Tibet shows that the development of the Tibetan Plateau has undergone mainly three stages of the uplift: the near-modern elevation of the central Tibet and significant uplift of the northern margins (~ 55–35 Ma), the further uplift of the plateau margins (30–20 Ma), and a rapid uplift of the plateau margins again (15–8 Ma). The first uplift of the plateau during ~ 55–35 Ma forced the long-term westward retreat of the Paratethys Sea. The high elevation of the central Tibet and/or the Himalayan would enhance rock weathering and erosion contributing to lowering of atmospheric CO 2 content, resulting in global cooling. The global cooling, sea retreat coupled with the topographic barrier effect of the Tibetan Plateau could have caused the initial aridification in central Asia during the Eocene time. The second uplift of the northern Tibet could have resulted in the onset of the East Asian winter monsoon as well as intensive desertification of inland Asia, whereas the central-eastern in China became wet. The further strengthening of the East Asian winter monsoon and the inland Asian aridification during 15–8 Ma was probably associated with the Tibetan Plateau uplift and global cooling. Therefore, the uplift of the Tibetan Plateau plays a very important role in the Asian aridification.