Cook Glacier drains a large proportion of the Wilkes Subglacial Basin in East Antarctica, a region thought to be vulnerable to marine ice sheet instability and with potential to make a significant contribution to sea-level. Despite its importance, there have been very few observations of its longer-term behaviour (e.g. of velocity or changes at its ice front). Here we use a variety of satellite imagery to produce a time-series of ice-front position change from 1947–2017 and ice velocity from 1973–2017. Cook Glacier has two distinct outlets (termed East and West) and we observe the near-complete loss of the Cook West Ice Shelf at some time between 1973 and 1989. This was associated with a doubling of the velocity of Cook West glacier, which may also be linked to previously published reports of inland thinning. The loss of the Cook West Ice Shelf is surprising given that the present-day ocean-climate conditions in the region are not typically associated with catastrophic ice shelf loss. However, we speculate that a more intense ocean-climate forcing in the mid-20 th century may have been important in forcing its collapse. Since the loss of the Cook West Ice Shelf, the presence of landfast sea-ice and mélange in the newly formed embayment appears to be important in stabilising the glacier front and enabling periodic advances. We also observe a short-lived increase in velocity of Cook East between 2006 and 2007 which we link to the drainage of subglacial Lake Cook. Taken together, these observations suggest that the velocity, and hence discharge, of Cook Glacier is highly sensitive to changes at its terminus but a more detailed process-based analysis of this potentially vulnerable region requires further oceanic and bathymetric data.