Atmospheric carbon monoxide (CO) and methane (CH 4 ) concentrations are measured by ground-based in-situ Cavity Ring-Down Spectroscopy (CRDS) analyzers and Fourier transform infrared (FTIR) spectrometers at two sites (St Denis and Maïdo) on Reunion Island (21° S, 55° E) in the Indian Ocean. Currently, the FTIR Bruker IFS 125HR at St Denis records the direct solar spectra in the near-infrared range, contributing to the Total Carbon Column Observing Network (TCCON). The FTIR Bruker IFS 125HR at Maïdo records the direct solar spectra in the mid-infrared range, contributing to the Network for the Detection of Atmospheric Composition Change (NDACC). In order to understand the atmospheric CO and CH 4 variability on Reunion Island, the time series and seasonal cycles of CO and CH 4 from in-situ and FTIR (NDACC and TCCON) measurements are analysed. Meanwhile, the difference between the in-situ and FTIR measurements are discussed. The CO seasonal cycles observed from the in-situ measurements at Maïdo and FTIR retrievals both at St Denis and Maïdo are in good agreement with a peak in September–November, primarily driven by the emissions from biomass burning in Africa and South America. The dry-air column averaged mole fraction of CO (X CO ) derived from the FTIR MIR spectra (NDACC) is about 15.7 ppb larger than the CO mole fraction near the surface at Maïdo, because the air in the lower troposphere mainly comes from the Indian Ocean while the air in the middle and upper troposphere mainly comes from Africa and South America. The trend for CO on Reunion Island is unclear during 2011–2017, and more data need to be collected to get a robust result. A very good agreement is observed in the tropospheric and stratospheric CH 4 seasonal cycles between FTIR (NDACC and TCCON) measurements, and in-situ and the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) satellite measurements, respectively. In the troposphere, the CH 4 mole fraction is high in August–September and low in December–January, which is due to the OH seasonal variation. In the stratosphere, CH 4 concentration has its maximum in March–April and its minimum in August–October, which is dominated by the vertical transport. In addition, the different CH 4 concentration between the in-situ, NDACC and TCCON CH 4 measurements in the troposphere are discussed, and all measurements are in good agreement with the GEOS-Chem model simulation. The trend of X CH 4 is 7.6 ± 0.4 ppb/year from the TCCON measurements over the 2011–2017 time period, which is consistent with the CH 4 of 7.4 ± 0.5 ppb/year from the in-situ measurements for the same time period at St Denis.